Oxidative stress suppresses PHB2‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway

Abstract Aims/Introduction Mitochondrial damage caused by oxidative stress is a main driver of pancreatic β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus. Prohibitin2 (PHB2) is a vital inner mitochondrial membrane protein that participates in mitophagy to remove the damaged mitoch...

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Bibliographic Details

Published in:	Journal of Diabetes Investigation
Main Authors:	Shan Liu, Rui Zhang, Lan Zhang, Aige Yang, Yuqing Guo, Lei Jiang, Huijuan Wang, Shunjiang Xu, Huimin Zhou
Format:	Article
Language:	English
Published:	Wiley 2024-05-01
Subjects:	Oxidative stress Prohibitin2 Type 2 diabetes mellitus
Online Access:	https://doi.org/10.1111/jdi.14147