Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury

To investigate microglial mechanisms in central and peripheral inflammation after experimental traumatic brain injury (TBI), we inhibited the colony-stimulating factor-1 receptor (CSF-1R) with PLX5622 (PLX). We hypothesized that microglia depletion would attenuate central inflammation acutely with n...

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Bibliographic Details

Published in:	Neurotrauma Reports
Main Authors:	Katherine R. Giordano, Maha Saber, Tabitha R.F. Green, Luisa M. Rojas-Valencia, J. Bryce Ortiz, Sean M. Murphy, Jonathan Lifshitz, Rachel K. Rowe
Format:	Article
Language:	English
Published:	Mary Ann Liebert 2023-04-01
Subjects:	concussion inflammation microglia peripheral immune response PLX
Online Access:	https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0092