Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro

Abstract Neurodegenerative diseases are often accompanied by neuroinflammation and impairment of the blood-brain barrier (BBB) mediated by activated glial cells through their release of proinflammatory molecules. To study the effects of glial cells on mouse brain endothelial cells (mBECs), we develo...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Annette Burkhart, Steinunn Sara Helgudóttir, Yahye A. Mahamed, Mikkel B. Fruergaard, Julie N. Holm-Jacobsen, Hulda Haraldsdóttir, Sara E. Dahl, Freja Pretzmann, Lisa Greve Routhe, Kate Lambertsen, Torben Moos, Maj Schneider Thomsen
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Subjects:	Blood-brain barrier Neuroinflammation In-vitro BBB model Glial cells Lipopolysaccharide
Online Access:	https://doi.org/10.1038/s41598-024-78204-w