Fever temperatures modulate intraprotein dynamics and enhance the binding affinity between monoclonal antibodies and the spike protein from SARS-CoV-2

Fever is a typical symptom of most infectious diseases. While prolonged fever may be clinically undesirable, mild reversible fever (<39℃, 312 K) can potentiate the immune responses against pathogens. Here, using molecular dynamics and free energy calculations, we investigated the effect of febril...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Dong Gun Kim, Hak Sung Kim, Yoonjoo Choi, Razvan Costin Stan
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	Fever Monoclonal antibodies SARS-CoV-2 Spike Binding affinity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037022004925