Virtual Screening and In Vitro Evaluation of PD-L1 Dimer Stabilizers for Uncoupling PD-1/PD-L1 Interaction from Natural Products

Genetic mutations accumulated overtime could generate many growth and survival advantages for cancer cells, but these mutations also mark cancer cells as targets to be eliminated by the immune system. To evade immune surveillance, cancer cells adopted different intrinsic molecules to suppress immune...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Jrhau Lung, Ming-Szu Hung, Yu-Ching Lin, Chien-Hui Hung, Chih-Cheng Chen, Kuan-Der Lee, Ying Huang Tsai
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	immunotherapy PD-1 PD-L1 small molecular inhibitor virtual screening
Online Access:	https://www.mdpi.com/1420-3049/25/22/5293