ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion

Loss or downregulation of major histocompatibility complex class I (MHC‐I) contributes to tumor immune evasion. We previously demonstrated that angiopoietin‐like protein 2 (ANGPTL2) promotes tumor progression using a Xp11.2 translocation renal cell carcinoma (tRCC) mouse model. However, molecular me...

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Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Tsuyoshi Kadomatsu, Chiaki Hara, Ryoma Kurahashi, Haruki Horiguchi, Jun Morinaga, Keishi Miyata, Sohtaro Kurano, Hisashi Kanemaru, Satoshi Fukushima, Kimi Araki, Masaya Baba, W. Marston Linehan, Tomomi Kamba, Yuichi Oike
Format:	Article
Language:	English
Published:	Wiley 2023-12-01
Subjects:	ANGPTL2 H3K27me3 MHC‐I PRC2 tumor immune evasion
Online Access:	https://doi.org/10.1002/1878-0261.13490