Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723

Abstract Background Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but failed to find any putative biosynthetic gene cluster that could account for its biosynthesis. Results Therefore, we seque...

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Bibliographic Details

Published in:	BMC Genomics
Main Authors:	Swati Sinha, Choy-Eng Nge, Chung Yan Leong, Veronica Ng, Sharon Crasta, Mohammad Alfatah, Falicia Goh, Kia-Ngee Low, Huibin Zhang, Prakash Arumugam, Alexander Lezhava, Swaine L. Chen, Yoganathan Kanagasundaram, Siew Bee Ng, Frank Eisenhaber, Birgit Eisenhaber
Format:	Article
Language:	English
Published:	BMC 2019-05-01
Subjects:	Cyclic lipodepsipeptide Biosynthetic gene cluster Combined NRPS/PKS cluster NonRibosomal Peptide Synthetase (NRPS) Adenylation domain Condensation domain
Online Access:	http://link.springer.com/article/10.1186/s12864-019-5762-6