The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets

Abstract Acetylcholine (ACh) is an essential neurotransmitter that has recently gained attention for its multifunctional role in tumor immune regulation. By binding neuronal loss to nicotinic and muscarinic receptors, ACh directly promotes tumor cell proliferation and migration while modulating immu...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Chunyu Zhang, Xiangdong Guo, Yanan Wang, Shuo Zhang, Zhihua Wang
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Acetylcholine Tumor immunity Nicotinic acetylcholine receptor Muscarinic acetylcholine receptor
Online Access:	https://doi.org/10.1186/s12943-025-02441-4