Donor selection for adoptive immunotherapy with NK cells in AML patients: Comparison between analysis of lytic NK cell clones and phenotypical identification of alloreactive NK cell repertoire

Natural killer (NK) cell-based adoptive immunotherapy in leukemia patients is an emerging field of interest based on clinical evidence of efficacy and safety. Elderly acute myeloid leukemia (AML) patients have been successfully treated with NK cells from HLA-haploidentical donors, especially when hi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Raffaella Meazza, Loredana Ruggeri, Fabio Guolo, Paola Minetto, Paolo Canevali, Fabrizio Loiacono, Sara Ciardelli, Alessandra Bo, Silvia Luchetti, Alberto Serio, Letizia Zannoni, Christelle Retière, Natalia Colomar-Carando, Sarah Parisi, Antonio Curti, Roberto M. Lemoli, Daniela Pende
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	natural killer cells (NK cells) donor selection NK alloreactivity killer immunoglobulin-like receptors (KIR) human leucocyte antigen (HLA) adoptive immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111419/full