A follow-up study: 6-year cART-free virologic control of rhesus macaques after PD-1-based DNA vaccination against pathogenic SHIVSF162P3CN challenge

ABSTRACT An effective vaccine for combination antiretroviral therapy (cART)-free virologic control of HIV-1 by enhancing antigen-specific effector-memory CD8+ T lymphocytes could be useful in controlling the AIDS pandemic. Previously, we demonstrated that a programmed death-1 (PD-1)-based DNA vaccin...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	Xiaoen He, Yik Chun Wong, Menglong Zhong, Yufei Mo, Bo Li, Lok Yan Yim, Xin Li, Wan Liu, Yanhua Du, Hui Wang, Haoji Zhang, Zhiwei Chen
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-12-01
Subjects:	long-term therapeutic efficacy SHIV HIV-1/AIDS therapeutic DNA vaccine PD-1
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.03350-23