Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation

KCNQ2-encoded Kv7.2 subunits play a critical role in balancing neuronal excitability. Mutations in KCNQ2 are responsible for highly-heterogenous epileptic and neurodevelopmental phenotypes ranging from self-limited familial neonatal epilepsy (SeLFNE) to severe developmental and epileptic encephalopa...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Fuyun Tian, Birong Cao, Haiyan Xu, Li Zhan, Fajun Nan, Ning Li, Maurizio Taglialatela, Zhaobing Gao
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Subjects:	KCNQ2 Epilepsy Mouse model HN37 (pynegabine)
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996122002522