Inflammasome activation and formation of ASC specks in patients with juvenile idiopathic arthritis

ObjectiveThe formation of large intracellular protein aggregates of the inflammasome adaptor ASC is a hallmark of inflammasome activation and characteristic of autoinflammation. Inflammasome activated cells release the highly proinflammatory cytokine IL-1β in addition to ASC specks into the extracel...

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發表在:	Frontiers in Medicine
Main Authors:	Nico Wittmann, Neha Mishra, Jana Gramenz, Daniela Kuthning, Ann-Kathrin Behrendt, Lukas Bossaller, Almut Meyer-Bahlburg
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2023-03-01
主題:	autoinflammation inflammasome apoptosis-associated speck-like protein (ASC) flow cytometry – methods juvenile idiopathic arthritis
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1063772/full