Toward Precision Dosing of Lamotrigine During Pregnancy: Physiologically Based Pharmacokinetic Modeling and Simulation

ABSTRACT Lamotrigine is a commonly used anti‐seizure medication in pregnant women. However, its pharmacokinetics (PK) during pregnancy markedly change, increasing the frequency of seizures and endangering the safety of the mother and fetus. Meanwhile, insufficient PK data on lamotrigine during pregn...

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Bibliographic Details

Published in:	CPT: Pharmacometrics & Systems Pharmacology
Main Authors:	Yudie Qian, Wanhong Wu, Chengjie Ke, Siting Liu, Jiarui Chen, Yuying Chen, Xianzhong Guo, Weiwei Lin
Format:	Article
Language:	English
Published:	Wiley 2025-05-01
Subjects:	fetus lamotrigine physiologically based pharmacokinetic model pregnancy
Online Access:	https://doi.org/10.1002/psp4.70007