Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients

Abstract Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize target drugs for pharmacogenomic approaches and gui...

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Bibliographic Details

Published in:	Clinical and Translational Science
Main Authors:	Morgan L. Shannon, Ayesha Muhammad, Nathan T. James, Michael L. Williams, Joseph Breeyear, Todd Edwards, Jonathan D. Mosley, Leena Choi, Prince Kannankeril, Sara Van Driest
Format:	Article
Language:	English
Published:	Wiley 2023-09-01
Online Access:	https://doi.org/10.1111/cts.13574