Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease

Abstract Background Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies reported that left frontoparietal network functional connectivity (LFPN-FC) confers resilience ag...

Full description

Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Jennifer Pahl, Prokopis C. Prokopiou, Elisenda Bueichekú, Aaron P. Schultz, Kathryn V. Papp, Michelle E. Farrell, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I.L. Jacobs
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Alzheimer’s disease Amyloid Attention Cognitive decline Left frontoparietal network Locus coeruleus
Online Access:	https://doi.org/10.1186/s13195-024-01485-w