USP8 modulates primary ovarian insufficiency through regulation of Beclin1-dependent autophagy-induced ferroptosis

Abstract The premature exhaustion of primordial follicles is a characteristic of primary ovarian insufficiency (POI), represents a profound disorder of ovarian function that leads to infertility, substantial impairments in daily activities, and enduring health risks. Despite its clinical significanc...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Yun Zhu, Haizhen Zhang, Lusha Lan, Xueru Chen, Limin Wei, Awei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-10-01
Subjects:
Ferroptosis
Granulosa cells
Lipid peroxidation
Primary ovarian insufficiency
USP8
Online Access:https://doi.org/10.1038/s41598-025-19876-w

Internet

https://doi.org/10.1038/s41598-025-19876-w

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