DPEP Inhibits Cancer Cell Glucose Uptake, Glycolysis and Survival by Upregulating Tumor Suppressor TXNIP

We have designed cell-penetrating peptides that target the leucine zipper transcription factors ATF5, CEBPB and CEBPD and that promote apoptotic death of a wide range of cancer cell types, but not normal cells, in vitro and in vivo. Though such peptides have the potential for clinical application, t...

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Bibliographic Details

Published in:	Cells
Main Authors:	Qing Zhou, Trang Thi Thu Nguyen, Jeong-Yeon Mun, Markus D. Siegelin, Lloyd A. Greene
Format:	Article
Language:	English
Published:	MDPI AG 2024-06-01
Subjects:	glucose uptake glycolysis TXNIP CEBPB CEBPD ATF5
Online Access:	https://www.mdpi.com/2073-4409/13/12/1025