Endoplasmic reticulum stress in pancreatic β-cell dysfunctionality and diabetes mellitus: a promising target for generation of functional hPSC-derived β-cells in vitro

Diabetes mellitus (DM), is a chronic disorder characterized by impaired glucose homeostasis that results from the loss or dysfunction of pancreatic β-cells leading to type 1 diabetes (T1DM) and type 2 diabetes (T2DM), respectively. Pancreatic β-cells rely to a great degree on their endoplasmic retic...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Abdoulaye Diane, Asma Allouch, Razik Bin Abdul Mu-U-Min, Heba Hussain Al-Siddiqi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	β-cells endoplasmic reticulum stress insulin diabetes mellitus hPSC-derived β-cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1386471/full