Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Abstract Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undru...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Tilman L. B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G. P. Grünewald, Maximilian M. L. Knott
Format:	Article
Language:	English
Published:	BMC 2022-10-01
Subjects:	Ewing sarcoma Rhabdomyosarcoma Fusion oncogene Targeted therapy Cancer gene therapy GPR64
Online Access:	https://doi.org/10.1186/s12943-022-01641-6