Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β

Abstract Introduction Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the proportion of 3R tau progressively increases. If this preferential accumu...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihara
Format:	Article
Language:	English
Published:	BMC 2018-01-01
Subjects:	Alzheimer disease pathology Tau isoform Human brain Virtual slide imaging Brainstem
Online Access:	http://link.springer.com/article/10.1186/s40478-017-0501-1