PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) plays a critical role in craniofacial development. Phosphatidylinositol 3-kinase (PI3K)/Akt is the primary effector of PDGFRα signaling during mouse skeletal development. We previously demonstrated that Akt phosphorylates t...

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Bibliographic Details

Published in:	eLife
Main Authors:	Thomas E Forman, Marcin P Sajek, Eric D Larson, Neelanjan Mukherjee, Katherine A Fantauzzo
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-12-01
Subjects:	mouse embryonic palatal mesenchyme PDGFRa Srsf3
Online Access:	https://elifesciences.org/articles/98531