Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis

Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6/Ube2l6) catalyzes protein ISGylation and ubiquitylation, post-translational modifications which regulate protein stability. Ube2l6 plays a role in promoting in vitro adipogenesis; however, its mechanism(s) of action and in vivo effects remain unknown....

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Weiping Wei, Yunqian Li, Yongyong Li, Daoyuan Li
Format:	Article
Language:	English
Published:	Elsevier 2021-04-01
Subjects:	Obesity Insulin resistance Adipocyte UBE2L6 ATGL
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861320301274