CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization

Abstract The CRISPR/Cas9 system easily edits target genes in various organisms and is used to treat human diseases. In most therapeutic CRISPR studies, ubiquitously expressed promoters, such as CMV, CAG, and EF1α, are used; however, gene editing is sometimes necessary only in specific cell types rel...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jinkyu Park, Gang Cui, Hyundong Lee, Han Jeong, Jay Jiyong Kwak, Junwon Lee, Suk Ho Byeon
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-03-01
Online Access:	https://doi.org/10.1038/s41598-023-29014-z