BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

ABSTRACT Moloney murine leukemia virus (MLV) infects BALB/c mice and induces T-cell lymphoma in mice. Retroviral integration is mediated by the interaction of the MLV integrase (IN) with members of the bromodomain and extraterminal motif (BET) protein family (BRD2, BRD3, and BRD4). The introduction...

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الحاوية / القاعدة:	Microbiology Spectrum
المؤلفون الرئيسيون:	Ivan Nombela, Martine Michiels, Dominique Van Looveren, Lukas Marcelis, Sara el Ashkar, Siska Van Belle, Anne Bruggemans, Thomas Tousseyn, Jürg Schwaller, Frauke Christ, Rik Gijsbers, Jan De Rijck, Zeger Debyser
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	American Society for Microbiology 2022-08-01
الموضوعات:	BALB/c mouse BET proteins BRD4 integrase integration site selection lymphomagenesis
الوصول للمادة أونلاين:	https://journals.asm.org/doi/10.1128/spectrum.01478-22