scDART: integrating unmatched scRNA-seq and scATAC-seq data and learning cross-modality relationship simultaneously

Abstract It is a challenging task to integrate scRNA-seq and scATAC-seq data obtained from different batches. Existing methods tend to use a pre-defined gene activity matrix to convert the scATAC-seq data into scRNA-seq data. The pre-defined gene activity matrix is often of low quality and does not...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Ziqi Zhang, Chengkai Yang, Xiuwei Zhang
Format:	Article
Language:	English
Published:	BMC 2022-06-01
Subjects:	scATAC-seq scRNA-seq Trajectory inference Integrative analysis Single-cell multiomics
Online Access:	https://doi.org/10.1186/s13059-022-02706-x