atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current ge...

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Bibliographic Details

Published in:	Emerging Infectious Diseases
Main Authors:	Laure Fournier Le Ray, Alexandra Aubry, Wladimir Sougakoff, Matthieu Revest, Jérôme Robert, Isabelle Bonnet, Nicolas Veziris, Florence Morel
Format:	Article
Language:	English
Published:	Centers for Disease Control and Prevention 2022-05-01
Subjects:	tuberculosis atpE bedaquiline MDR TB XDR TB Rv0678
Online Access:	https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article