Necroptosis-mediated HMGB1 secretion of keratinocytes as a key step for inflammation development in contact hypersensitivity

Abstract Keratinocyte necroptosis (with proinflammatory characteristic) is required for epidermal damage in contact hypersensitivity (CHS). In DNCB-induced CHS mice model, we observed the aggravated keratinocyte death and increased phosphorylation level of MLKL, RIPK3 and RIPK1. However, CHS skin le...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Ni Lian, Yujie Chen, Sihan Chen, Ta Xiao, Changjun Song, Yangying Ke, Xuecui Wei, Chunyan Gong, Hui Yu, Heng Gu, Qing Chen, Min Li, Xu Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2022-11-01
Online Access:	https://doi.org/10.1038/s41420-022-01228-6