Silymarin protects mouse liver and kidney from thioacetamide induced toxicity by scavenging reactive oxygen species and activating PI3K-Akt pathway

Abstract:Silymarin (SMN) has been shown to possess a wide range of biological and pharmacological effects. Besides, SMN has antioxidant and free radical scavenging activities. Thioacetamide (TAA) is a well-documented liver toxin that requires oxidative bioactivation to elicit its hepatotoxic effect...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Shatadal Ghosh, Abhijit Sarkar, Sudip Bhattacharyya, Parames C. Sil
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-12-01
Subjects:	Kidney Liver Silymarin Thioacetamide apoptosis. Oxidative damage
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00481/full