Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13–driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells

Background: The immunologic mechanisms underlying pulmonary type 2 inflammation, including the dynamics of eosinophil recruitment to the lungs, still need to be elucidated. Objective: We sought to investigate how IL-13–producing TH2 effector cells trigger eosinophil migration in house dust mite (HDM...

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Bibliographic Details

Published in:	Journal of Allergy and Clinical Immunology: Global
Main Authors:	Pedro H. Gazzinelli-Guimaraes, PhD, Dominic P. Golec, PhD, Erik P. Karmele, PhD, Joshua Sciurba, BSc, Pablo Bara-Garcia, MSc, Tom Hill, PhD, Byunghyun Kang, PhD, Sasisekhar Bennuru, PhD, Pamela L. Schwartzberg, MD, Thomas B. Nutman, MD
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	Type 2 inflammation eosinophils allergy asthma IL-13 signaling CCL-11
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772829323000565