Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3<i>S</i>,4<i>S</i>)-3-Amino-4-fluorocyclopentenecarboxylic Acid

Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we found that (3<i>S</i>,4<i>S</i>)-3-amino-4-fluorocyclopentenecarboxylic acid (<b>5</b>)...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Sida Shen, Arseniy Butrin, Brett A. Beaupre, Glaucio M. Ferreira, Peter F. Doubleday, Daniel H. Grass, Wei Zhu, Neil L. Kelleher, Graham R. Moran, Dali Liu, Richard B. Silverman
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	aminotransferase mechanism-based inactivators enamine cyclopentene mechanistic studies
Online Access:	https://www.mdpi.com/1420-3049/28/3/1133