Decoupled tricarboxylic acid cycle and glycolysis of Corynebacterium glutamicum combined with acetate supply promote high-yield biosynthesis of l-homoserine

l-Homoserine is a valuable intermediate with broad applications in the food, pharmaceutical, and chemical industries. Although Corynebacterium glutamicum has been engineered for the efficient biosynthesis of l-homoserine, both production efficiency and glucose conversion remain suboptimal. In this s...

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Bibliographic Details

Published in:	Synthetic and Systems Biotechnology
Main Authors:	Daobin Wang, Lu Xu, Junwen Yuan, Ruisi Wu, Xiyao Cheng, Jidong Liu, Ning Li
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-12-01
Subjects:	Corynebacterium glutamicum l-homoserine TCA EMP Acetate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405805X25001097