Comparative analysis of small molecule and growth factor-derived human induced pluripotent stem cell-derived hepatocyte-like cells

The growth factor and small molecule protocol are the two primary approaches for generating human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs). We compared the efficacy of the growth factor and small molecule protocols across fifteen different human iPSC lines. Morphologic...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Faizal Z. Asumda, Shadia Alzoubi, Kiyasha Padarath, Kimya Jones, Ravindra Kolhe, Ashis Kumar Mondal, Ahmet Alptekin, Wenbo Zhi, Tae Jin Lee, Robert C. Huebert, Nathan P. Staff, Lewis R. Roberts, Lindsey A. Kirkeby
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	hepatocytes hepatocyte-like cells induced pluripotent stem cells growth factors small molecules
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1594340/full