Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy due to its unclear pathogenesis. Caffeic acid phenethyl ester (CAPE), which is obtained from honeybee propolis and medic...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Antioxidants
المؤلفون الرئيسيون:	Yue Wang, Ziwen Cai, Gaofeng Zhan, Xing Li, Shan Li, Xuan Wang, Shiyong Li, Ailin Luo
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2023-03-01
الموضوعات:	postoperative cognitive dysfunction (POCD) caffeic acid phenethyl ester (CAPE) Sirt6/Nrf2 pathway microglia polarization oxidative stress neuroinflammation
الوصول للمادة أونلاين:	https://www.mdpi.com/2076-3921/12/3/714