Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction

Present study explores the role of liver lipidome in driving T2D-associated metabolic changes. Elevated liver triacylglycerols, reduced PUFAs, and 86 differentially abundant lipid species were identified in diabetes-prone mice. Of these altered lipid species, 82 markedly overlap with human plasma li...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Ratika Sehgal, Markus Jähnert, Michail Lazaratos, Thilo Speckmann, Fabian Schumacher, Burkhard Kleuser, Meriem Ouni, Wenke Jonas, Annette Schürmann
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Subjects:	lipid species type 2 diabetes obesity New Zealand obese mice diabetes-prone/resistant
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227525000276