Cardiac copper content and its relationship with heart physiology: Insights based on quantitative genetic and functional analyses using BXD family mice

BackgroundCopper (Cu) is essential for the functioning of various enzymes involved in important cellular and physiological processes. Although critical for normal cardiac function, excessive accumulation, or deficiency of Cu in the myocardium is detrimental to the heart. Fluctuations in cardiac Cu c...

Full description

Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Akhilesh Kumar Bajpai, Qingqing Gu, Buyan-Ochir Orgil, Fuyi Xu, Carolina Torres-Rojas, Wenyuan Zhao, Chen Chen, Athena Starlard-Davenport, Byron Jones, Djamel Lebeche, Jeffrey A. Towbin, Enkhsaikhan Purevjav, Lu Lu, Wenjing Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	BXD cardiac Cu homeostasis systems genetics hypertrophy cardiomyopathy genetic mapping
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1089963/full