Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection

Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncoprotein CagA leading to loss of cell polarity, but the precise...

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Bibliographic Details

Published in:	Cell Insight
Main Authors:	Irshad Sharafutdinov, Aileen Harrer, Mathias Müsken, Klemens Rottner, Heinrich Sticht, Christian Täger, Michael Naumann, Nicole Tegtmeyer, Steffen Backert
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	CagA T4SS Cortactin Par1b ZO-1 ASPP2
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772892724000166