Vitamin D Receptor-Dependent Protective Effect of Moderate Hypoxia in a Mouse Colitis Model

Although hypoxia is important for maintaining the intestinal barrier, its effect on the barrier during acute colitis and the underlying mechanisms are not fully understood. To explore the influence of hypoxia in dextran sulfate sodium (DSS)-induced colitis mice and the role of hypoxia-inducible fact...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Zheng Wang, Hong Yang, Hong Lv, Changzhi Huang, Jiaming Qian
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Subjects:	hypoxia Vitamin D receptor (VDR) intestinal barrier DSS-induced colitis HIF-1α (hypoxia inducible factor-1α)
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.876890/full