Acute Lung Functional and Airway Remodeling Effects of an Inhaled Highly Selective Phosphodiesterase 4 Inhibitor in Ventilated Preterm Lambs Exposed to Chorioamnionitis

Phosphodiesterase (PDE) inhibition has been identified in animal studies as a new treatment option for neonatal lung injury, and as potentially beneficial for early lung development and function. However, our group could show that the inhaled PDE4 inhibitor GSK256066 could have dose-dependent detrim...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Matthias Christian Hütten, Tim Brokken, Helene Widowski, Tobias Monaco, Jan Philipp Schneider, Markus Fehrholz, Daan Ophelders, Boris W. Kramer, Steffen Kunzmann
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	PDE inhibitors neonatal lung injury respiratory distress syndrome bronchopulmonary dysplasia
Online Access:	https://www.mdpi.com/1424-8247/16/1/29