Structural insights of anti-MHC-I monoclonal antibodies that block NK cell receptor interactions with tumors

We have recently shown that certain anti-MHC-I mAbs in human and murine systems can stimulate immune responses to tumors and infections by competitively blocking inhibitory signals delivered by MHC-I-specific inhibitory receptors of several inflammatory cell types [1,2]. To understand such functions...

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Bibliographic Details

Published in:	Structural Dynamics
Main Authors:	Jiansheng Jiang, Kannan Natarajan, Abir Panda, Lisa F. Boyd, Reanne Towler, Haotian Lei, Rick Huang, Ethan M. Shevach, David H. Margulies
Format:	Article
Language:	English
Published:	AIP Publishing LLC and ACA 2025-10-01
Online Access:	https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A325/20775311/a325_1_4.0001114.pdf