IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice

Abstract The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is limited due to T cell-mediated rejection, which also persists after induction with anti-thymocyte globulin (ATG). Here, we investigate why ATG fails to prevent costimulation blockade-resistant rejection...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Moritz Muckenhuber, Konstantinos Mengrelis, Anna Marianne Weijler, Romy Steiner, Verena Kainz, Marlena Buresch, Heinz Regele, Sophia Derdak, Anna Kubetz, Thomas Wekerle
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Online Access:	https://doi.org/10.1038/s41467-024-48574-w