Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration

Summary: The existence of slow-cycling luminal cells in the prostate has been suggested, but their identity and functional properties remain unknown. Using a bigenic mouse model to earmark, isolate, and characterize the quiescent stem-like cells, we identify a label-retaining cell (LRC) population i...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Dingxiao Zhang, Collene Jeter, Shuai Gong, Amanda Tracz, Yue Lu, Jianjun Shen, Dean G. Tang
Format:	Article
Language:	English
Published:	Elsevier 2018-01-01
Subjects:	prostate stem cells luminal progenitors label-retaining cells quiescence prostate cancer prostate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117305234