Co-administration of temozolomide (TMZ) and the experimental therapeutic targeting miR-10b, profoundly affects the tumorigenic phenotype of human glioblastoma cells

Introduction: Recent studies have shown that miRNA-10b is highly expressed in high-grade glioblastoma multiforme (GBM), and its inhibition leads to deregulation of multiple pathways in tumorigenesis, resulting in repression of tumor growth and increased apoptosis. Thus, we hypothesized that suppress...

Full description

Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Ming Chen, Bryan Kim, Neil Robertson, Sujan Kumar Mondal, Zdravka Medarova, Anna Moore
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	glioblastoma multiforme microRNA temozolomide in vitro studies nanoparticles
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1179343/full