Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes
Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA. Several prominent anti-cancer agents inhibit TOP2 by stabilizing the cleavage complex and engende...
| الحاوية / القاعدة: | Molecules |
|---|---|
| المؤلفون الرئيسيون: | , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI AG
2014-06-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.mdpi.com/1420-3049/19/6/7415 |