Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulation of liver metabolism

Background:Penthorum chinense Pursh (PCP) is widely utilized in China to treat a variety of liver diseases. It has been shown that flavonoids inhibit inflammation and have the potential to attenuate tissue damage and fibrosis. However, the mechanisms underlying how total flavonoids isolated from PCP...

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出版年:	Frontiers in Pharmacology
主要な著者:	Sujuan Wang, Wenqing Li, Wenxiu Liu, Lei Yu, Fu Peng, Junyuan Qin, Lin Pu, Yunli Tang, Xiaofang Xie, Cheng Peng
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2023-11-01
主題:	Penthorum chinense Pursh total flavonoids hepatic fibrosis inflammation liver metabolomics TLR4/MyD88/NF-κB pathways
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1253013/full