Analysis of riociguat and desmethyl riociguat by UPLC-MS/MS and its interaction with quercetin

Riociguat, an orally soluble guanylate cyclase (sGC)-promoting drug, is mainly used in the clinical treatment of pulmonary hypertension (PH). In this study, a novel ultra-performance liquid chromatography-tandem mass spectrometry method was developed to quantify the concentrations of riociguat and i...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Qingqing Li, Xiaohai Chen, Siping Zhang, Wanshu Li, Hangjuan Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	riociguat desmethyl riociguat quercetin UPLC-MS/MS drug-drug interaction
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1470377/full