Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia

While mild hyperthermia holds great potential in the treatment of solid tumors, the thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed of thermosensitive poly(ethylene glycol)-polypeptide cop...

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Bibliographic Details

Published in:	Bioactive Materials
Main Authors:	Yaoben Wang, Xiaobin Chen, Zhiyong Chen, Xin Wang, Hancheng Wang, Huajuan Zhai, Jiandong Ding, Lin Yu
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2024-09-01
Subjects:	Mild hyperthermia Magnetic hyperthermia therapy (MHT) Autophagy inhibition Nitric oxide (NO) Injectable hydrogel
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X24001981