Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected half a billion people, including vulnerable populations such as cancer patients. While increasing evidence supports the persistence of SARS-CoV-2 months after a negative nasopharyngeal swab test, the effects on long-term immun...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Mai Chan Lau, Yang Yi, Denise Goh, Chun Chau Lawrence Cheung, Benedict Tan, Jeffrey Chun Tatt Lim, Craig Ryan Joseph, Felicia Wee, Justina Nadia Lee, Xinru Lim, Chun Jye Lim, Wei Qiang Leow, Jing Yi Lee, Cedric Chuan Young Ng, Hamed Bashiri, Peng Chung Cheow, Chun Yip Chan, Ye Xin Koh, Thuan Tong Tan, Shirin Kalimuddin, Wai Meng David Tai, Jia Lin Ng, Jenny Guek-Hong Low, Tony Kiat Hon Lim, Jin Liu, Joe Poh Sheng Yeong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	case report SARS-CoV-2 spatial transcriptomics intra-tumor heterogeneity tissue-localized immunity immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.978760/full