Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome

About 20% of individuals afflicted with thoracic aortic disease have single-gene mutations that predispose the vessel to aneurysm formation and/or acute aortic dissection often without associated syndromic features. One widely studied exception is Marfan syndrome (MFS) in which mutations in the extr...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Keiichi Asano, Anna Cantalupo, Lauriane Sedes, Francesco Ramirez
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Subjects:	angiotensin II arterial disease endothelial dysfunction Marfan syndrome NO signaling oxidative stress
Online Access:	https://www.mdpi.com/2218-273X/12/1/128