Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib

The sterile inflammatory response mediated by Toll-like receptors (TLRs) 4 and 9 is implicated in the massive hepatic damage caused by acetaminophen (APAP)-overdose. There is a crosstalk between TLR-dependent signaling with other intracellular kinases like phosphatidylinositol 3-kinases (PI3Ks). Nev...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Mohamed E. Shaker, Hesham A. M. Gomaa, Sara H. Hazem, Mohamed A. Abdelgawad, Mohamed El-Mesery, Ahmed A. Shaaban
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	alpelisib phosphatidylinositol 3-kinase acetaminophen hepatotoxicity DAMPs
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1212771/full