Focused ultrasound-mediated temozolomide delivery into intact blood–brain barrier tissue improves survival in patient-derived xenograft model of glioblastoma

Abstract Background Glioblastoma (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by rapid proliferation and invasive infiltration into normal brain tissue. Despite maximal resection and temozolomide (TMZ) chemotherapy, over 80% of GBM cases recur near the rese...

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Bibliographic Details

Published in:	Fluids and Barriers of the CNS
Main Authors:	Jaewoo Shin, Jin-Kyoung Shim, Chanho Kong, Younghee Seo, Sangheon Han, Seok-Gu Kang, Won Seok Chang
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Blood–brain barrier Focused ultrasound Glioblastoma Temozolomide Tumorsphere
Online Access:	https://doi.org/10.1186/s12987-025-00695-0